LIB
 

ConjoinG ID: CGHSA0708

Conjoined Gene Summary
Conjoined Gene Symbol ENTPD4-LOXL2
mRNA/EST(s) used as evidence AW504925;
Parent HGNC Gene Symbols ENTPD4; LOXL2;
(Parent genes belong to different gene family)
Known Conjoined Gene No
Identified By Conjoin
Genomic Context
Chromosome 8
Location (Strand) 8p21.3-p21.2 (–)
mRNA/EST Genomic Location Table [ View ]
Distance between Parent Genes 28.41 Kb (Non-Overlapping)
ENTPD4 LOXL2 ENTPD4_LOXL2 NM_004901 23,371,015-23,371,081 23,363,351-23,363,455 23,362,200-23,362,397 23,361,138-23,361,343 23,357,914-23,358,064 23,357,308-23,357,411 23,355,465-23,355,524 23,355,027-23,355,181 23,353,207-23,353,373 23,350,392-23,350,716 23,348,850-23,348,935 23,347,775-23,347,936 23,346,078-23,346,612 23,363,351-23,363,358 23,362,200-23,362,397 23,361,138-23,361,343 23,357,914-23,358,064 23,357,308-23,357,411 23,355,465-23,355,524 23,355,027-23,355,181 23,353,207-23,353,373 23,350,392-23,350,716 23,348,850-23,348,935 23,347,775-23,347,936 23,346,384-23,346,612 NM_002318 23,317,412-23,317,667 23,281,455-23,281,892 23,273,548-23,273,723 23,254,450-23,254,661 23,246,859-23,247,081 23,241,840-23,242,023 23,235,588-23,235,739 23,233,343-23,233,510 23,230,407-23,230,572 23,223,126-23,223,369 23,216,740-23,216,855 23,215,485-23,215,621 23,212,294-23,212,405 23,210,355-23,211,580 23,281,455-23,281,809 23,273,548-23,273,723 23,254,450-23,254,661 23,246,859-23,247,081 23,241,840-23,242,023 23,235,588-23,235,739 23,233,343-23,233,510 23,230,407-23,230,572 23,223,126-23,223,369 23,216,740-23,216,855 23,215,485-23,215,621 23,212,294-23,212,405 23,211,501-23,211,580 AW504925 23,350,392-23,350,598 23,348,850-23,348,935 23,347,775-23,347,936 23,281,857-23,281,892 ENTPD4 LOXL2 ENTPD4_LOXL2 NM_004901 23,371,015-23,371,081 23,363,351-23,363,455 23,362,200-23,362,397 23,361,138-23,361,343 23,357,914-23,358,064 23,357,308-23,357,411 23,355,465-23,355,524 23,355,027-23,355,181 23,353,207-23,353,373 23,350,392-23,350,716 23,348,850-23,348,935 23,347,775-23,347,936 23,346,078-23,346,612 NM_002318 23,317,412-23,317,667 23,281,455-23,281,892 23,273,548-23,273,723 23,254,450-23,254,661 23,246,859-23,247,081 23,241,840-23,242,023 23,235,588-23,235,739 23,233,343-23,233,510 23,230,407-23,230,572 23,223,126-23,223,369 23,216,740-23,216,855 23,215,485-23,215,621 23,212,294-23,212,405 23,210,355-23,211,580 AW504925 23,350,392-23,350,598 23,348,850-23,348,935 23,347,775-23,347,936 23,281,857-23,281,892 ENTPD4 LOXL2 ENTPD4_LOXL2 NM_004901 23,363,351-23,363,358 23,362,200-23,362,397 23,361,138-23,361,343 23,357,914-23,358,064 23,357,308-23,357,411 23,355,465-23,355,524 23,355,027-23,355,181 23,353,207-23,353,373 23,350,392-23,350,716 23,348,850-23,348,935 23,347,775-23,347,936 23,346,384-23,346,612 NM_002318 23,281,455-23,281,809 23,273,548-23,273,723 23,254,450-23,254,661 23,246,859-23,247,081 23,241,840-23,242,023 23,235,588-23,235,739 23,233,343-23,233,510 23,230,407-23,230,572 23,223,126-23,223,369 23,216,740-23,216,855 23,215,485-23,215,621 23,212,294-23,212,405 23,211,501-23,211,580
5' Parent Gene
Entrez Gene ID 9583
HGNC Official Gene Symbol ENTPD4
HGNC Official Full Name ectonucleoside triphosphate diphosphohydrolase 4
Aliases LAP70; LALP70; LYSAL1; UDPase; KIAA0392; NTPDase-4
NCBI RefSeq mRNA NM_001128930
Other mRNAs NM_004901
NCBI RefSeq Protein NP_001122402.1
Gene Ontology
Function calcium ion binding;hydrolase activity;magnesium ion binding;uridine-diphosphatase activity
Process UDP catabolic process
Component Golgi apparatus;Golgi membrane;cytoplasmic vesicle;integral to Golgi membrane;integral to membrane;membrane
KOG Classification Metabolism ( F – Nucleotide transport and metabolism [KOG1386] )
OMIM Disorders
NA
Tissues Expression (UniGene)
Adult, blastocyst, bone, bone marrow, brain, breast (mammary gland) tumor, chondrosarcoma, colorectal tumor, connective tissue, embryoid body, embryonic tissue, esophageal tumor, esophagus, eye, fetus, gastrointestinal tumor, germ cell tumor, glioma, head and neck tumor, heart, infant, intestine, juvenile, kidney, kidney tumor, larynx, leukemia, liver, liver tumor, lung, lung tumor, lymph node, mammary gland, mouth, muscle, non-neoplasia, normal, ovarian tumor, ovary, pancreas, pancreatic tumor, pituitary gland, placenta, primitive neuroectodermal tumor of the CNS, prostate, prostate cancer, retinoblastoma, skin, soft tissue/muscle tissue tumor, spleen, stomach, testis, thymus, thyroid, trachea, uterine tumor, uterus, vascular
Entrez Gene Summary
NA
3' Parent Gene
Entrez Gene ID 4017
HGNC Official Gene Symbol LOXL2
HGNC Official Full Name lysyl oxidase-like 2
Aliases LOR2; WS9-14
NCBI RefSeq mRNA NM_002318
Other mRNAs NA
NCBI RefSeq Protein NP_002309.1
Gene Ontology
Function copper ion binding;electron carrier activity;metal ion binding;oxidoreductase activity;protein-lysine 6-oxidase activity;scavenger receptor activity
Process aging;cell adhesion;oxidation reduction;protein modification process
Component extracellular region;extracellular space;membrane
KOG Classification NA
OMIM Disorders
NA
Tissues Expression (UniGene)
Adipose tissue, adult, blastocyst, bone, brain, breast (mammary gland) tumor, cervical tumor, cervix, chondrosarcoma, colorectal tumor, connective tissue, ear, embryoid body, embryonic tissue, eye, fetus, gastrointestinal tumor, germ cell tumor, glioma, head and neck tumor, heart, infant, intestine, juvenile, kidney, kidney tumor, leukemia, liver, liver tumor, lung, lung tumor, lymph, lymph node, lymphoma, mammary gland, mouth, muscle, neonate, non-neoplasia, normal, ovarian tumor, ovary, pancreas, pancreatic tumor, placenta, primitive neuroectodermal tumor of the CNS, prostate, prostate cancer, retinoblastoma, skin, skin tumor, soft tissue/muscle tissue tumor, spleen, stomach, testis, thymus, thyroid, trachea, umbilical cord, uterine tumor, uterus, vascular
Entrez Gene Summary
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]
General Protein Information
CG Conservation
Experimental Validation
Conjoined gene confirmed by PCR Not Attempted Experimentally