LIB
 

ConjoinG ID: CGHSA0641

Conjoined Gene Summary
Conjoined Gene Symbol DAB2-C9
mRNA/EST(s) used as evidence DA647993;
Parent HGNC Gene Symbols DAB2; C9;
(Parent genes belong to different gene family)
Known Conjoined Gene No
Identified By Conjoin
Genomic Context
Chromosome 5
Location (Strand) 5p14-p12 (–)
mRNA/EST Genomic Location Table [ View ]
Distance between Parent Genes 8.09 Kb (Non-Overlapping)
DAB2 C9 DAB2_C9 NM_001343 39,460,663-39,460,703 39,430,089-39,430,280 39,429,113-39,429,252 39,428,224-39,428,322 39,426,303-39,426,434 39,425,711-39,425,791 39,424,956-39,424,982 39,424,658-39,424,711 39,424,164-39,424,226 39,418,477-39,419,130 39,417,313-39,417,475 39,412,509-39,413,141 39,411,856-39,411,965 39,410,873-39,410,943 39,408,503-39,409,284 39,430,089-39,430,179 39,429,113-39,429,252 39,428,224-39,428,322 39,426,303-39,426,434 39,425,711-39,425,791 39,424,956-39,424,982 39,424,658-39,424,711 39,424,164-39,424,226 39,418,477-39,419,130 39,417,313-39,417,475 39,412,509-39,413,141 39,411,856-39,411,965 39,410,878-39,410,943 NM_001737 39,400,247-39,400,412 39,377,950-39,378,055 39,377,415-39,377,559 39,377,005-39,377,152 39,367,535-39,367,673 39,351,634-39,351,888 39,346,996-39,347,236 39,344,089-39,344,217 39,342,476-39,342,651 39,324,582-39,324,810 39,320,765-39,321,092 39,400,247-39,400,323 39,377,950-39,378,055 39,377,415-39,377,559 39,377,005-39,377,152 39,367,535-39,367,673 39,351,634-39,351,888 39,346,996-39,347,236 39,344,089-39,344,217 39,342,476-39,342,651 39,324,582-39,324,810 39,321,058-39,321,092 DA647993 39,460,663-39,460,727 39,424,658-39,424,711 39,377,950-39,378,055 39,377,415-39,377,559 39,377,005-39,377,152 39,367,632-39,367,673 DAB2 C9 DAB2_C9 NM_001343 39,460,663-39,460,703 39,430,089-39,430,280 39,429,113-39,429,252 39,428,224-39,428,322 39,426,303-39,426,434 39,425,711-39,425,791 39,424,956-39,424,982 39,424,658-39,424,711 39,424,164-39,424,226 39,418,477-39,419,130 39,417,313-39,417,475 39,412,509-39,413,141 39,411,856-39,411,965 39,410,873-39,410,943 39,408,503-39,409,284 NM_001737 39,400,247-39,400,412 39,377,950-39,378,055 39,377,415-39,377,559 39,377,005-39,377,152 39,367,535-39,367,673 39,351,634-39,351,888 39,346,996-39,347,236 39,344,089-39,344,217 39,342,476-39,342,651 39,324,582-39,324,810 39,320,765-39,321,092 DA647993 39,460,663-39,460,727 39,424,658-39,424,711 39,377,950-39,378,055 39,377,415-39,377,559 39,377,005-39,377,152 39,367,632-39,367,673 DAB2 C9 DAB2_C9 NM_001343 39,430,089-39,430,179 39,429,113-39,429,252 39,428,224-39,428,322 39,426,303-39,426,434 39,425,711-39,425,791 39,424,956-39,424,982 39,424,658-39,424,711 39,424,164-39,424,226 39,418,477-39,419,130 39,417,313-39,417,475 39,412,509-39,413,141 39,411,856-39,411,965 39,410,878-39,410,943 NM_001737 39,400,247-39,400,323 39,377,950-39,378,055 39,377,415-39,377,559 39,377,005-39,377,152 39,367,535-39,367,673 39,351,634-39,351,888 39,346,996-39,347,236 39,344,089-39,344,217 39,342,476-39,342,651 39,324,582-39,324,810 39,321,058-39,321,092
5' Parent Gene
Entrez Gene ID 1601
HGNC Official Gene Symbol DAB2
HGNC Official Full Name disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Aliases DOC2; DOC-2; FLJ26626
NCBI RefSeq mRNA NM_001343
Other mRNAs NA
NCBI RefSeq Protein NP_001334.2
Gene Ontology
Function protein C-terminus binding
Process cell proliferation
Component coated pit;cytoplasmic vesicle;membrane
KOG Classification Cellular processes and signaling ( T – Signal transduction mechanisms [KOG3535] )
OMIM Disorders
NA
Tissues Expression (UniGene)
Adipose tissue, adrenal gland, adrenal tumor, adult, ascites, bladder carcinoma, blood, bone, bone marrow, brain, breast (mammary gland) tumor, cervical tumor, cervix, chondrosarcoma, colorectal tumor, connective tissue, ear, embryoid body, embryonic tissue, esophageal tumor, esophagus, eye, fetus, gastrointestinal tumor, germ cell tumor, glioma, head and neck tumor, heart, intestine, juvenile, kidney, kidney tumor, larynx, leukemia, liver, liver tumor, lung, lung tumor, lymph node, lymphoma, mammary gland, mouth, muscle, neonate, nerve, non-neoplasia, normal, ovarian tumor, ovary, pancreas, pancreatic tumor, parathyroid, placenta, prostate, prostate cancer, salivary gland, skin, skin tumor, soft tissue/muscle tissue tumor, spleen, stomach, testis, thymus, thyroid, trachea, umbilical cord, uterine tumor, uterus, vascular
Entrez Gene Summary
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta). [provided by RefSeq]
3' Parent Gene
Entrez Gene ID 735
HGNC Official Gene Symbol C9
HGNC Official Full Name complement component 9
Aliases NA
NCBI RefSeq mRNA NM_001737
Other mRNAs NA
NCBI RefSeq Protein NP_001728.1
Gene Ontology
Function NA
Process caspase activation;complement activation, alternative pathway;complement activation, classical pathway;cytolysis;hemolysis by symbiont of host red blood cells;induction of apoptosis
Component integral to plasma membrane;membrane;membrane attack complex
KOG Classification NA
OMIM Disorders
C9 deficiency (3)
C9 deficiency with dermatomyositis (3)
Tissues Expression (UniGene)
Adult, fetus, kidney, liver, liver tumor, muscle, normal, pancreas, pancreatic tumor, placenta
Entrez Gene Summary
NA
General Protein Information
CG Conservation
Experimental Validation
Conjoined gene confirmed by PCR Attempted but not confirmed
Accession used for PCR confirmationDA647993
Confirmed tissues in which CG is expressed
Other details[UCSC image] [Primer details`][PCR sequences]